KC BRANAGHANS

Pasta and Pint Nite

Pasta and Pint Nite

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It’s Pasta and Pint Nite
All you can eat pasta

*Rigatoni Bolognese
(w/ Italian Sausage and Short Ribs)
*Stroganoff
( w/ Filet Mignon)
*Rigatoni Pesto
(Our homemade recipe w/ Sun Dried Tomatoes)
*Fettuccine Alfredo
(w/homemade Alfredo Sauce)
Just $10.95!
……………………………………………….

Pint of the Night
Great Divide’s
Heyday

An eminently pleasant Belgian-Style White Ale.

Brewed with barley, oats and raw wheat, it is uniquely
flavorful for such an easy-drinking ale.

With a slightly cloudy appearance and traditional
yeast, it is a balanced,agreeable offering.

Exuding mild hop bitterness and a nuanced body,
this is the easiest decision you’ll make all day.
$100 Giveaway

Claudia Bachetti was not here

to win the $800 tonight

She is a loser!!

Comedy Thursday

Laughter for a Cause

This Thursday night is going to be a night full of laughter.
We are having a Comedy Fundraiser beginning at 7:30 PM

Some of the funniest comedians in Long Beach
will be here to entertain you. We will donate a portion of what you spend to the
Breast Cancer Angels (https://www.facebook.com/pages/Breast-Cancer-Angels/177723177350) , so bring your wallet.

Outright donations will also be accepted.

Monday-Friday
Breakfast Special

Join us for our $4.99 Breakfast Special, Monday-Friday from 7:00am to Noon.

Eggs, bacon, Potatoes , toast.

Bottomless Mimosas Available.

MLB
Angels/Rangers 5:05pm

============================================================
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  58. The first investigation of the in vitro efficacy of plant
    extracts in opposition to HP was printed in 1991 . This group reported that extracts of 13 Malagasy medicinal plants have been efficient against a
    number of medical strains of HP in vitro. In 1996, Fabry and associates reported that a number of East African medicinal plant extracts had inhibitory effects on the expansion of HP in vitro .
    One plant, Terminalia spinosa was reported to be essentially the most
    active, with an MIC vary 62.5-500 mg/ml. Extracts of Thymus vulgaris
    and Cinnamonum zeylanicum have been additionally reported to inhibit the expansion of the bacterium at concentrations of3.5 mg/ml .

    In 1997, investigators discovered that frequent food vegetation corresponding to garlic, soybean and fresh vegetables may be protective in opposition to HP infections [78-79].

    104 The strain was isolated from homogenates of a sponge belonging to the genus Microomnospora.
    The macrolide showed a really strong cytotoxic activity
    in opposition to P-388, and low however significant
    exercise against A-549, HT-29, and MEL-28 cell traces; it showed antibiotic activity towards Micrococcus
    luteus as properly.

    Chemical Constituents Of The Family Mycalidae

    Similar variation in the content of 3-APs has been detected
    even inside a single sponge species collected from
    totally different geographical areas , suggesting that the setting can influence their secondary metabolism.
    The majority of natural three-APs isolated so far are monomeric compounds differing in the
    size, saturation, branching and termination of the alkyl chains.
    These compounds often present cytotoxic and/or antibacterial actions at concentrations of a
    few micrograms per mL. A smaller variety of oligomeric and polymeric
    3-APs have additionally been isolated and partially characterised.
    It is clearly evident that polymeric 3APs exert many more diverse and
    potent organic activities. Most of the 3-APs that have been isolated thus far are listed in accordance
    with their fundamental structural varieties.
    Recently, two new non-sulfated hexoglycosides,
    parvimosides A (fifty seven!) and B , Fig. have been isolated from the ocean cucumber Stichopus parvimensis .

    Holothurin 57f is said to holotoxin B, the distinction being the
    absence of a double bond at position 25 within the aglycone of parvimoside A (57!).

    On the opposite hand, parvimoside B is the 25-dihydroderivative of holotoxin B] .

    values of3.9 and 10.three nM in opposition to KB and LoVo cell traces respectively.

    It required a better focus than dolastatin 10 to disrupt microtubules for its weaker in vitro
    cytotoxicity. The acyclic peptide tasiamide 139 was isolated from the marine cyanobacterium Symploca Sp.97 collected at Short Drop-off in Palau.
    Tasiamide was cytotoxic towards KB and LoVo cells with IC so values of
    zero.forty eight and 3.4711g mL- 1, respectively.

    Further evaluation of the zootoxicities of the holothurins 57d and 57e and their
    desulfated analog using the brine shrimp (Artemia salina L.) larvae mortality
    bioassay showed that hemoiedemoside A had a noteworthy toxicity (LC so 18.7 ppm).
    Hemoiedemoside B was 2 times much less energetic (LC so 47.5 ppm) than 57d and almost 10 times extra energetic than the desulfated by-product (LC so 424.5 ppm).

    Thus sea cucumber glycosides are strong but not absolute defenses in opposition to
    various predators. Glycosides of sea cucumbers can inhibit the expansion of larvae
    of marine organisms, significantly sea-urchin embryos, containing cholesterol within the cell membranes .
    Sea cucumbers and sea urchins occupy quite totally different niches as Levin accurately noted, and aren’t competitors
    . Therefore, it isn’t acceptable to attribute inhibition of sea-urchin improvement as a specific function of glycosides.
    However, seaurchin embryos may be a good model for investigation of allelopathic action of sea cucumber glycosides.
    The glycosides of Cucumaria echinata demonstrated an action on shellfish in culture .
    Sea cucumber glycosides may play an essential role in defending
    the physique floor from fouling by different organisms.

    Extracts with an MIC of a hundred.0 ~g/ml included Pouzolzia pentandra
    , Cycas siamensis , Litsea elliptica and Melaleuca quinquenervia .
    Ginger root , a plant well-known worldwide to treat gastrointestinal ailments additionally has exercise in opposition to HP
    . Methanol extracts of ginger rhizome inhibited the growth of 19 HP
    strains in vitro with a minimal inhibitory focus range of 6.25-50 ~g/ml.
    6, all had various degrees of exercise, with an MIC vary of zero.seventy eight
    to 12.5 ~g/ml and interestingly had important exercise against the cagA+ strains .

    Cytotoxic exercise of three-alkylpyridine and three-alkylpyridinium compounds from marine sponges on completely different cell traces.

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    An aqueous extract of garlic inhibited the expansion of HP strains at concentrations of forty Jlg/ml .
    Rabdosia trichocarpa, a conventional treatment for gastric and
    stomachic complaints in Japan, was also inhibits the growth of HP in vitro .
    A diterpene named trichorabdal A, isolated from the plant showed very robust in vitro antibacterial exercise against HP,
    as well . In 1999, the anti-HP results of seven Turkish plant extracts, used in folks medication for the therapy
    of gastric illnesses including peptic ulcers, was reported .
    Extracts of the flowers of Cistus laurifolius, cones of Cedrus libani, aerial parts of Centaurea solstitialis ssp.
    solstitialis, fruits of Momordica charantia,
    aerial elements of Sambucus ebulus, and flowering herbs of Hypericum perforatum have been active with an MIC vary of between 1.95 and
    250 mg/ml . In 2003, a screening of 20 plant extracts from Thailand used to treat gastrointestinal ailments reported that over 50% of the plant species examined had anti-HP activity .

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    Betancour et al. reported for the primary time the antiherpetic activity of a series of sponge-derived diterpenes.
    A household of 13 new diterpene glycosides, pseudopterosins P-Z,
    Fig. , and secopseudopterosins H and I actually have
    been isolated from two collections of the marine sponge Pseudopterogorgia elisabethae from the Southwestern Caribbean sea in Colombia .
    Pseudopterosin P displayed strong antiviral exercise
    in opposition to HSV-l, HSV-2 and VZV. have also been isolated from the blue
    coral Heliopora coerulea . Helioporins A and B confirmed
    antiviral exercise in opposition to HSV-l. Comin et al.
    isolated disulphated polyhydroxysteroids with inhibitory effect on the replication of HSV-2 from the Antarctic ophiuroid Astrotoma agassizii.

    However, it is our belief that ALL-1 may not characterize a
    novel advanced.

    Apparently, all these components have been found to coexist at the promoter of
    the HoxA9 gene in vivo .

    The ALL-1/MLL-1 proteins operate in transcriptional activation as ALL-1 to methylate lysine-four of histone H3,
    which is known to be concerned in transcription activity .

    The putative ALL-1 complicated additionally included subunits of the RNA polymerase II-associated TFIID advanced, in addition to subunits of the chromatin reworking complexes
    SNF2h, Swi/Snf, NuRD, and Sin3.

    The presence of HDACs is according to the need to deacetylate specific residues in histone H3 for his or her subsequent methylation.

    On the opposite hand, hemoiedemoside B was much less energetic that 57d.
    These outcomes recommend that each the construction of the triterpenoidal aglycone
    and the presence and variety of the sulfate teams at
    the oligosaccharide chain might play a significant position within the antifungal activity of those saponins.

    extra active than cucumarioside A whereas cucumarioside G j was
    not energetic in the identical assay. Two trisulfated tetrasaccharide glycosides, liouvillosides A and B isolated from the Antarctic
    sea cucumber Staurocucumis liouvillei were discovered to be
    antiviral against herpes simplex virus type I (HSV-1) at concentrations below 10 I-lg/ml.
    Glycoside 89 is distinguished from 88 only by the absence of a 24-double bond within the facet chain of the
    aglycon .

    Complete Natural Merchandise Ii: Chemistry And Biology:
    Volume 5

    The crude aqueous extract from the leaves of Helichrysum litoreum at
    a concentration of 1.35 mg/ml confirmed important antiviral
    activity on HSV-1 in human lung fibroblasts, as demonstrated by the absence of cytopathic impact .
    Baccharis dracunculifolia DC from the genus Baccharis, is a local plant from Brazil, and crucial botanical origin for the manufacturing of green propolis by honeybees.
    Propolis and plant secretions are derived from three species
    most frequently mentioned as botanical sources of the bee glue in Brazil, including
    Baccharis dracunculifolia . Recently, Leitao et al. demonstrated that extracts of this plant produced a basteriostatic effect on Streptococcus mutans cultures.

    33 Structures of trapoxins A and B Enamidonin Enamidonin was
    found by Koshino et al. in 1995, from Streptomyces sp.
    throughout screening for inhibitors of the mitogenic
    activity of epidermal growth factor. Enamidonin inhibits epidermal development factor-dependent
    uptake of 3H-thymidine into Balb/MK cells with an IC so of 10llg/ml.
    This compound reverses the remodeled morphology of src-ts-NRK to the traditional flat morphology with
    an ED so of 101lg/ml. The anti-herpes simplex virus sort I
    (HSV-l) activity of diethyl ether extract from the flowering tops of this plant had been also
    investigated . The extract showed important antiviral exercise at concentrations ranging from 400 to one
    hundred flg/ml.
    in the forthcoming construction elucidation of such complex
    classes of compounds. Finally, the supra-molecular construction of poly-APS has been also
    studied by dynamic mild scattering measurements. These information suggest that in aqueous resolution poly-APS are primarily organized as noncovalently certain aggregates, an interesting
    characteristic which could be answerable for the
    wide range of organic actions reported on these compounds .
    chemical markers for the systematic determination of haplosclerid sponges
    . However, not all such sponges contain three-AP compounds.
    For example, only one species of Haliclona out of five collected within the Adriatic Sea contained
    three-APs (T. Turk, unpublished knowledge).

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    with an amino, N-methoxylamine, or oxime methyl ether performance at the finish of the alkyl chain had been subsequently
    purified . Assuming the gross construction of niphatesine D to have been correctly assigned, Romeril et al.
    forged doubts on the right task of the S-absolute stereochemistry of 6 based on optical
    rotation. The stereochemistry was first assigned by Rao and Reddy by the synthesis of6 and then confirmed by Bracher and Papke .

    at the tested concentrations (l.5-50 /-lg/spot), whereas patagonicoside A was less lively (eight-19 mm)
    on the similar concentrations.
    These results correlated with the info on antifungal exercise.
    Most of the members of the Stichopodidae family (Stichopus japonica , Stichopus
    chloronotus , Parastichopus californius and Bohadschia bivittata ) have been proven to
    produce hexosides as main elements of the glycosidic fraction.
    They are non-sulfated glycosides with a linear three-0-Me-Glc-(l three 3)-G1c-(lfour 4)-Xyl
    chain and a branching of a linear trisaccharide at C-2 of the
    xylose unit. The only examples with a glucose unit instead of
    the terminal 3-zero-Me-glucose are holotoxin B] and B .

    Propolis samples collected within the dry and rainy
    season from an experimental apiary situated in cerrado vegetation in Brazil had been investigated by Santos et al.

    . Antibacterial assays have been carried out by the strategy of dilution of
    an ethanol extract of propolis in agar, and confirmed that
    each one sixteen actinomycete strains examined had been inhibited by propolis concentrations of 0.1 to
    0.25%. Regarding antibacterial activity, each extracts of Baccharis grisebachii have been lively on methicillin-resistant
    and methicillinsensitive Staphylococcus aureus, with minimal inhibitory concentrations from a hundred twenty five to 500 flg/ml.

    Fungicidal exercise of untamed vegetation growing in Mexico was evaluated in opposition to the mould species Aspergillus jlavus,
    Aspergillus niger, Penicillium chrysogenum, Penicillium
    expansum, Fusarium moniliforme and Fusarium poae .
    Two mould species have been managed by Baccharis glutinosa Pers.

    Other Baccharis species with antiviral properties also included Baccharis teindalensis L.
    that some plant-primarily based medicines would have activity in opposition to HP in vitro.

    To verify this function, Levin noted surfaces of most sea cucumbers aren’t fouled but Psolus species, covered with overlapping calcareous plates have only
    slightly toxic glycosides and very often are fouled with
    sponges, algae etc. The excessive antifungal exercise of sea cucumber glycosides could present a protecting action against some fungi.
    Apparently organic functions of triterpene glycosides, which initially had been only regulatory ones,
    later became broader. Therefore, external features have appeared
    as a secondary evolutionary response of sea cucumbers to fish predation .

    Uses For Steroids

    Another structural characteristic in three~-hydroxyholost-9-ene aglycones is
    the presence of a 12a-hydroxyl group, such as in the
    hexaglycoside bivittoside D , Fig. Bivittoside D,
    widespread in sea cucumbers belonging to the genus Bohadschia was described by
    Hedge et al. as a brand new compound within the sea cucumber recognized as Telenata ananas.

    Kalinin et al. thought of that this taxonomic classification pertains to Thelenota ananas for the reason that genus Telenata has
    never been described for sea cucumbers. A novel bioactive macrolide, IB , was isolated from the fermentation broth
    of a marine actinomycete, L-25-ES20-008.

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